Abstract This article introduced the ICBEST (integrative, cognitive, behavioral, energy and spiritual therapy) model for guiding therapy and change, using an extensive, single case study of a highly depressed, suicidal client. Five of the eight levels of the PPPT (Positive Pressure Point Techniques) were used as the energy therapy approach in addition to Integrative Forgiveness Psychotherapy (IFP). In addition, the Practice Based Evidence Approach (PBEA) to assessment and change was used to demonstrate dramatic client changes over time. Short scales to track change were administered on a regular basis in the areas of stress, depression, negative affect and beliefs, positive affect and beliefs, well-being, flourishing, life satisfaction, self-worth, self-compassion, forgiveness, gratitude and marital positivity and cohesion. The clients scores showed major decreases in overall stress and negative affect, depression, suicidal ideation, neuroticism and vulnerability, and major increases in well-being, flourishing, positive affect and beliefs, self-compassion and self-worth, life satisfaction, warmth, marital positivity and straightforwardness.