This study explored the effects of prayer and meditating for others as assessed by the global health measure of quality of life (QOL). Participants recruited from around the United States were asked to pray or meditate for 2 people every day for 4 weeks. Pretest and posttest scores on the SF-36 quality of life questionnaire showed improvements in 8 out of 10 QOL measures, with significant improvements in vitality (p < .034), decreased bodily pain (p < .011) and trends of improvement in general health (p < .067) and restrictions resulting from emotional problems (p < .097).